The CDC revised its yellow fever guidance on June 11 2026 for parts of Brazil, Peru and Colombia. Vaccination is now recommended for travel to 12 additional provinces previously considered low risk. The change follows recent case reports in previously unaffected areas.
A single dose of the vaccine provides lifelong immunity according to current WHO standards. Travellers must carry the International Certificate of Vaccination or Prophylaxis for border checks. Several South American countries already enforce the requirement for incoming passengers.
Yellow fever outbreaks have occurred sporadically in the Amazon basin since 2022. Health authorities in the three countries requested updated CDC alignment to protect both residents and visitors. US clinics report increased demand for the vaccine ahead of the northern hemisphere summer.
The CDC maintains an interactive map showing exact provinces requiring vaccination. Airlines have been notified to verify certificates at check-in for affected routes. No changes were made to requirements for Africa at this time.
What this means for you
Check the CDC travel health notice for your exact itinerary at least four weeks before departure. Schedule vaccination at a designated yellow fever clinic and obtain the stamped certificate immediately. Keep a digital photo of the certificate on your phone as backup.
Confirm entry rules with the embassy of each country you plan to visit. Avoid last-minute bookings to regions now listed as high risk. Review your travel insurance for medical evacuation coverage in remote areas.
Future updates may add or remove provinces depending on surveillance data. Travellers should recheck the CDC site within 30 days of any South America trip.